Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.6
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+

Top Medical Research Studies

9
Probiotic lowers cholesterol in hamsters
We explored the effects of the CNCM I-745 probiotic on cholesterol levels and gut bacteria in hamsters with high cholesterol. This controlled study revealed that daily doses significantly lowered total plasma cholesterol and altered gut microbiota. Specifically, we noted that the abundance of certain gut microbes was linked to changes in cholesterol levels and liver gene expression. These findings suggest that this probiotic not only benefits cholesterol levels but also supports gut health, offering potential for safe treatments in managing hypercholesterolemia.
Read More
8
S. boulardii reduces lung injury
We explored the effects of the probiotic Saccharomyces boulardii on lung injury caused by aortic ischemia-reperfusion in rats. Twenty-one rats were divided into three groups, one receiving the probiotic and others receiving saline.

After the aorta was clamped, we noticed that those treated with S. boulardii experienced significantly less lung damage and reduced oxidative stress. This suggests the probiotic helps lower inflammation and oxidative stress markers, potentially leading to better outcomes in cardiovascular procedures.
Read More
7
Probiotic yeast improves heart-healthy fats
This innovative study evaluated how adding the probiotic yeast Saccharomyces boulardii to buckwheat sprouts affects their fatty acid composition. Through careful analysis, we found that this modification leads to noteworthy changes in fatty acids, including palmitic and oleic acids.

These changes may enhance the nutritional value of buckwheat sprouts, potentially contributing to a reduced risk of cardiovascular disease. Overall, our findings suggest that probiotic-rich buckwheat sprouts could serve as a functional dietary option for heart health.
Read More

Most Useful Reviews

9
Improved gut health
1 people found this helpful
My journey to better gut health led me to Garden of Life’s Primal Defense Ultra. After using it consistently for a month, I can confidently say it met my expectations. The potent blend of probiotics has greatly improved my digestive regularity, significantly reducing bloating and discomfort. I've also noticed stronger immunity and fewer colds, likely due to better gut health. Although the price point may deter some, the benefits justify the cost. Initially, I experienced mild discomfort as my body adjusted, but it passed with continued use.
Read More
9
Immediate effectiveness
11 people found this helpful
Great composition. This product significantly improved my health after a severe intestinal disease and numerous antibiotics. I had tried nearly all probiotics available in Russia, but nothing worked. Remarkably, this product had an effect almost immediately, within about a week. I highly recommend it.
Read More
9
Quick recovery
3 people found this helpful
This product is exceptionally effective! I used it after suffering a serious intestinal disease and taking many antibiotics. I had tried almost every probiotic in Russia, and nothing helped, but this product had an effect almost immediately, within about a week. I highly praise it and would recommend it without hesitation.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.6
  • All Researches
9
Probiotic lowers cholesterol in hamsters
We explored the effects of the CNCM I-745 probiotic on cholesterol levels and gut bacteria in hamsters with high cholesterol. This controlled study revealed that daily doses significantly lowered total plasma cholesterol and altered gut microbiota. Specifically, we noted that the abundance of certain gut microbes was linked to changes in cholesterol levels and liver gene expression. These findings suggest that this probiotic not only benefits cholesterol levels but also supports gut health, offering potential for safe treatments in managing hypercholesterolemia.
Read More
8
S. boulardii reduces lung injury
We explored the effects of the probiotic Saccharomyces boulardii on lung injury caused by aortic ischemia-reperfusion in rats. Twenty-one rats were divided into three groups, one receiving the probiotic and others receiving saline.

After the aorta was clamped, we noticed that those treated with S. boulardii experienced significantly less lung damage and reduced oxidative stress. This suggests the probiotic helps lower inflammation and oxidative stress markers, potentially leading to better outcomes in cardiovascular procedures.
Read More
7
We explored the role of selenium and zinc enriched postbiotic yeast in addressing gut dysbiosis linked to cardiovascular disease. This study involved analyzing the effects of these postbiotics on microbial populations in the digestive system using various scientific methods.

We found that treatment with the enriched postbiotics led to a notable increase in beneficial bacteria and acetic acid levels. These results suggest that selenium and zinc postbiotics may hold therapeutic potential as adjuncts in treating cardiovascular diseases by improving gut health.
Read More
7
Probiotic yeast improves heart-healthy fats
This innovative study evaluated how adding the probiotic yeast Saccharomyces boulardii to buckwheat sprouts affects their fatty acid composition. Through careful analysis, we found that this modification leads to noteworthy changes in fatty acids, including palmitic and oleic acids.

These changes may enhance the nutritional value of buckwheat sprouts, potentially contributing to a reduced risk of cardiovascular disease. Overall, our findings suggest that probiotic-rich buckwheat sprouts could serve as a functional dietary option for heart health.
Read More
7
Reduced remnant lipoprotein observed
We investigated how the probiotic yeast Saccharomyces boulardii affects blood cholesterol levels in adults with high cholesterol. In this single-arm, open-label pilot study, twelve participants took a specified dose of S. boulardii for eight weeks. While we monitored various cholesterol levels and cardiovascular health markers, results showed a noteworthy reduction in remnant lipoprotein, which could play a role in preventing coronary artery disease. However, overall cholesterol levels did not significantly change during the study.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.6
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Improved gut health
1 people found this helpful
My journey to better gut health led me to Garden of Life’s Primal Defense Ultra. After using it consistently for a month, I can confidently say it met my expectations. The potent blend of probiotics has greatly improved my digestive regularity, significantly reducing bloating and discomfort. I've also noticed stronger immunity and fewer colds, likely due to better gut health. Although the price point may deter some, the benefits justify the cost. Initially, I experienced mild discomfort as my body adjusted, but it passed with continued use.
Read More
9
Immediate effectiveness
11 people found this helpful
Great composition. This product significantly improved my health after a severe intestinal disease and numerous antibiotics. I had tried nearly all probiotics available in Russia, but nothing worked. Remarkably, this product had an effect almost immediately, within about a week. I highly recommend it.
Read More
9
Quick recovery
3 people found this helpful
This product is exceptionally effective! I used it after suffering a serious intestinal disease and taking many antibiotics. I had tried almost every probiotic in Russia, and nothing helped, but this product had an effect almost immediately, within about a week. I highly praise it and would recommend it without hesitation.
Read More

Frequently Asked Questions

9
Immediate effectiveness
11 people found this helpful
Great composition. This product significantly improved my health after a severe intestinal disease and numerous antibiotics. I had tried nearly all probiotics available in Russia, but nothing worked. Remarkably, this product had an effect almost immediately, within about a week. I highly recommend it.
9
Quick recovery
3 people found this helpful
This product is exceptionally effective! I used it after suffering a serious intestinal disease and taking many antibiotics. I had tried almost every probiotic in Russia, and nothing helped, but this product had an effect almost immediately, within about a week. I highly praise it and would recommend it without hesitation.
9
Improved gut health
1 people found this helpful
My journey to better gut health led me to Garden of Life’s Primal Defense Ultra. After using it consistently for a month, I can confidently say it met my expectations. The potent blend of probiotics has greatly improved my digestive regularity, significantly reducing bloating and discomfort. I've also noticed stronger immunity and fewer colds, likely due to better gut health. Although the price point may deter some, the benefits justify the cost. Initially, I experienced mild discomfort as my body adjusted, but it passed with continued use.
7
We explored the role of selenium and zinc enriched postbiotic yeast in addressing gut dysbiosis linked to cardiovascular disease. This study involved analyzing the effects of these postbiotics on microbial populations in the digestive system using various scientific methods.

We found that treatment with the enriched postbiotics led to a notable increase in beneficial bacteria and acetic acid levels. These results suggest that selenium and zinc postbiotics may hold therapeutic potential as adjuncts in treating cardiovascular diseases by improving gut health.
8
S. boulardii reduces lung injury
We explored the effects of the probiotic Saccharomyces boulardii on lung injury caused by aortic ischemia-reperfusion in rats. Twenty-one rats were divided into three groups, one receiving the probiotic and others receiving saline.

After the aorta was clamped, we noticed that those treated with S. boulardii experienced significantly less lung damage and reduced oxidative stress. This suggests the probiotic helps lower inflammation and oxidative stress markers, potentially leading to better outcomes in cardiovascular procedures.
7
Probiotic yeast improves heart-healthy fats
This innovative study evaluated how adding the probiotic yeast Saccharomyces boulardii to buckwheat sprouts affects their fatty acid composition. Through careful analysis, we found that this modification leads to noteworthy changes in fatty acids, including palmitic and oleic acids.

These changes may enhance the nutritional value of buckwheat sprouts, potentially contributing to a reduced risk of cardiovascular disease. Overall, our findings suggest that probiotic-rich buckwheat sprouts could serve as a functional dietary option for heart health.
9
Probiotic lowers cholesterol in hamsters
We explored the effects of the CNCM I-745 probiotic on cholesterol levels and gut bacteria in hamsters with high cholesterol. This controlled study revealed that daily doses significantly lowered total plasma cholesterol and altered gut microbiota. Specifically, we noted that the abundance of certain gut microbes was linked to changes in cholesterol levels and liver gene expression. These findings suggest that this probiotic not only benefits cholesterol levels but also supports gut health, offering potential for safe treatments in managing hypercholesterolemia.
7
Reduced remnant lipoprotein observed
We investigated how the probiotic yeast Saccharomyces boulardii affects blood cholesterol levels in adults with high cholesterol. In this single-arm, open-label pilot study, twelve participants took a specified dose of S. boulardii for eight weeks. While we monitored various cholesterol levels and cardiovascular health markers, results showed a noteworthy reduction in remnant lipoprotein, which could play a role in preventing coronary artery disease. However, overall cholesterol levels did not significantly change during the study.

References

  1. Dinu LD, Gatea F, Matei F, Banciu C, Vamanu E. Gut Microbiota Modulation by Selenium and Zinc Enrichment Postbiotic on Dysbiosis Associated with Hypertension. Curr Vasc Pharmacol. 2024;22:365. doi:10.2174/0115701611290537240509061549
  2. Durmaz S, Kurtoğlu T, Barbarus E, Çetin NK, Yılmaz M, et al. Probiotic Saccharomyces boulardii Alleviates Lung Injury by Reduction of Oxidative Stress and Cytokine Response Induced by Supraceliac Aortic Ischemia-Reperfusion Injury in Rats. Braz J Cardiovasc Surg. 2021;36:515. doi:10.21470/1678-9741-2020-0153
  3. Molska M, Reguła J, Rudzińska M, Świeca M. Fatty acids profile, atherogenic and thrombogenic health lipid indices of lyophilized buckwheat sprouts modified with the addition of Saccharomyces cerevisiae var. boulardii. Acta Sci Pol Technol Aliment. 2020;19:483. doi:10.17306/J.AFS.0866
  4. Briand F, Sulpice T, Giammarinaro P, Roux X. changes lipidemic profile and gut microbiota in a hamster hypercholesterolemic model. Benef Microbes. 2019;10:555. doi:10.3920/BM2018.0134
  5. Ryan JJ, Hanes DA, Schafer MB, Mikolai J, Zwickey H. Effect of the Probiotic Saccharomyces boulardii on Cholesterol and Lipoprotein Particles in Hypercholesterolemic Adults: A Single-Arm, Open-Label Pilot Study. J Altern Complement Med. 2015;21:288. doi:10.1089/acm.2014.0063
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